Formulation and Evaluation of ZnO-loaded levofloxacin nanoparticles to fight Salmonella typhi
Keywords:
Levofloxacin, Toxicity, Antimicrobial, Salmonella typhiAbstract
Nanomaterials containing inorganic metallic ions are commonly employed to treat various illnesses, including cancer, autoimmune disorders, and bacterial and fungal colonization. In this study, Zn-loaded levofloxacin nanoparticles (ZLFNs) are used as an antibacterial agent. The adsorption-produced nanocarriers were examined using FTIR, SEM, TEM, and HPLC. Simulated body fluid was used in in vitro release experiments at 37 °C. Data were evaluated using a variety of kinetic models, which revealed a slow dissolution for 12 to 24 hours. Research on antimicrobial agents revealed enhanced efficaciousness against Salmonella typhi. It was experimentally found that ZLFNs possessed a particle size of 140.1 nm with a zeta potential value of -19.8 mV and had a good encapsulation efficiency of 87-91%.
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