Gene Editing Technologies: Ethical Considerations and Regulatory Frameworks
Keywords:
Gene Editing, CRISPR-Cas9, Ethical Considerations, Regulatory Frameworks, Genome EditingAbstract
The ethical considerations and regulatory frameworks surrounding gene editing
technologies such as CRISPR-Cas9. We explore the potential applications of gene editing in medicine, agriculture, and biotechnology, as well as the ethical dilemmas raised by the ability to manipulate the human genome. Through a review of international guidelines, bioethical principles, and public debates, we analyze the ethical implications of gene editing for issues such as genetic enhancement, germline editing, and equitable access to genetic therapies. Our research aims to inform policymakers, scientists, and the public about the ethical challenges and governance mechanisms needed to ensure responsible and equitable use of gene editing technologies in the life sciences.
References
Doudna, Jennifer A., and Samuel H. Sternberg. A Crack in Creation: Gene Editing and
the Unthinkable Power to Control Evolution. Houghton Mifflin Harcourt, 2017.
National Academies of Sciences, Engineering, and Medicine. Human Genome Editing:
Science, Ethics, and Governance. The National Academies Press, 2017.
Regalado, Antonio. The Gene Hackers. MIT Technology Review, 2015.
National Institutes of Health. Ethical Considerations in Human Biomedical Research.
Office for Human Research Protections, 2016.
Church, George M., and Ed Regis. Regenesis: How Synthetic Biology Will Reinvent
Nature and Ourselves. Basic Books, 2012.
Berg, Paul, et al. Potential Biohazards of Recombinant DNA Molecules. Science, vol.
, no. 4148, 1974, pp. 303-306.
Charo, R. Alta. The Legal and Regulatory Context for Human Gene Editing. JAMA,
vol. 313, no. 12, 2015, pp. 1215-1216.
Jasanoff, Sheila. The Ethics of Invention: Technology and the Human Future. W.W.
Norton & Company, 2016.
Cavaliere, Giulia, et al. Human Germline Genome Editing. American Journal of
Bioethics, vol. 20, no. 4, 2020, pp. 3-17.
Committee on Gene Drive Research in Non-Human Organisms: Recommendations for
Responsible Conduct, Board on Life Sciences, and Division on Earth and Life Studies.
Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning
Research with Public Values. The National Academies Press, 2016.
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