Exploring the Role of MicroRNAs in Cancer Progression: A Comprehensive Review
Keywords:
MicroRNAs, Cancer progression, Gene expression regulation, Tumor initiationAbstract
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and key players in cancer progression. This comprehensive review explores the multifaceted roles of miRNAs in cancer biology, including their involvement in tumor initiation, metastasis, angiogenesis, and drug resistance. We summarize the current understanding of miRNA biogenesis, regulation, and function, highlighting their dysregulation in various cancer types and their potential diagnostic, prognostic, and therapeutic implications. Additionally, we discuss recent advancements in miRNA-based therapies, including miRNA mimics, inhibitors, and delivery strategies, and their translation into clinical applications. By elucidating the complex interplay between miRNAs and cancer progression, this review aims to provide insights into novel therapeutic targets and strategies for the management of cancer.
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